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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Logan plot ： ウィキペディア英語版 Logan plot A Logan plot (or Logan graphical analysis) is a graphical analysis technique based on the compartment model that uses linear regression to analyze pharmacokinetics of tracers involving reversible uptake. It is mainly used for the evaluation of nuclear medicine imaging data after the injection of a labeled ligand that binds reversibly to specific receptor or enzyme. In conventional compartmental analysis, an iterative method is used to fit the individual model parameters in the solution of a compartmental model of specific configuration to the measurements with a measured plasma time-activity curve that serves as an forcing (input) function, and the binding of the tracer can then be described. Graphical analysis is a simplified method that transforms the model equations into a linear equation evaluated at multiple time points and provides fewer parameters (i.e., slope and intercept). Although the slope and the intercept can be interpreted in terms of a combination of model parameters if a compartmental model configuration is assumed, the graphical methods are independent of any specific model configuration. In case of irreversible tracers, certain fraction of the radioactivity is trapped in the tissue or the binding site during the course of the experiment, whereas reversible tracers show uptake and loss from all compartments throughout the study. The theoretical foundation of graphical analysis for irreversible tracers (also called Patlak graphical analysis or Patlak plot) was laid by Clifford Patlak and his colleagues at NIH. Based on the original work of Patlak, Jean Logan and her colleagues〔 from Brookhaven National Laboratory extended the method to tracers with reversible kinetics. == Description == The kinetics of radiolabeled compounds in a compartmental system can be described in terms of a set of first-order, constant-coefficient, ordinary differential equations. The time course of the activity in the multicompartmental system driven by a metabolite-corrected plasma input function $C\_p(t)$ can be described by: : $\backslash frac\; =\; \backslash mathbf\; +\; \backslash mathbfC\_p(t)$ where $\backslash mathbf$ is a column vector of activity concentration for each compartment at time $t$, $\backslash mathbf$ is the matrix of the transfer constants between compartments, and $\backslash mathbf$ is the vector of plasma-to-tissue transfer constants. Patlak and Blasberg〔 showed that the above equation can be written as: : $\backslash int\_0^t\; A(\backslash tau)\; \backslash ,\; d\backslash tau\; =\; -\backslash mathbf\_n^T\; \backslash mathbf^\; \backslash mathbf\; \backslash int\_0^t\; C\_p(\backslash tau)\; \backslash ,\; d\backslash tau\; +\; \backslash mathbf\_n^T\; \backslash mathbf^\; \backslash mathbf$ where $\backslash mathbf\_n^T$ represents a row vector of 1s and $A(t)\; =\; \backslash mathbf\_n^T\; \backslash mathbf$. The total activity in the region of interest, $\backslash mathrm(t)$, is a combination of radioactivities from all compartments plus a plasma volume fraction ($V\_p$)〔 and thus: : $\backslash int\_0^t\; \backslash mathrm(\backslash tau)\; \backslash ,\; d\backslash tau\; =\; (-\backslash mathbf\_n^T\; \backslash mathbf^\; \backslash mathbf\; +V\_p)\; \backslash int\_0^t\; C\_p(\backslash tau)\; \backslash ,\; d\backslash tau\; +\; \backslash mathbf\_n^T\; \backslash mathbf^\; \backslash mathbf$ By dividing both sides by $\backslash mathrm(t)$, one obtains the following linear equation: : $$ For $t\; >\; t\text{'}$, Patlak and his colleagues〔 showed that $\backslash mathbf\; =\; -\backslash mathbf^\; \backslash mathbf\; C\_p(t)$, i.e., the steady-state condition. When this condition is satisfied, the intercept has reached its constant value so that after some time a plot of $$.〔 For a catenary two-tissue compartment model with transfer constants $K\_1$ (forward transport from plasma to tissue), $k\_2$ (reverse transport from tissue to plasma), $k\_3$ (binding parameter proportional to $B\_\backslash max\; k\_\backslash mathrm$), and $k\_4$ (dissociation constant) to analyze enzyme or receptor system, the slope represents the total distribution volume ($V\_d$) and is given by $\backslash frac(1+\backslash frac)\; +\; V\_p$,〔 where $k\_3\; =\; B\_\backslash max\; k\_\backslash mathrm$, $k\_4\; =\; k\_\backslash mathrm$, $\backslash frac\; =\; \backslash frac$, and $K\_d\; =\; k\_\backslash mathrm/k\_\backslash mathrm$, in which $B\_\backslash max$ is the concentration of ligand binding sites, $K\_d$ is the equilibrium dissociation constant for the ligand-binding site complex, $k\_\backslash mathrm$ is the ligand-binding association constant, $k\_\backslash mathrm$ is the ligand-binding dissociation constant. For a one-tissue compartment model with transfer constants $K\_1$ and $k\_2$, the slope is $\backslash lambda\; +\; V\_p$, where $\backslash lambda$ is the partition coefficient ($/$) and the intercept is $\backslash frac$.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Logan plot」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.